Reference Library

Led by Science

We are a science-led brand. Better outcomes start with understanding the biology of skin — not with following trends. Every statement on this site is backed by peer-reviewed research, clinical evidence, internal data, and years of real-world experience gathered across many countries. We keep innovating to do better: to support the skin's own structure in a way that looks and feels natural, rather than only masking what shows on the surface.

Cao M, Tao L, Zhang Y, et al. Increasing collagen synthesis in fibroblasts: the roles of PCL microspheres and the SAMD11-PLOD1 axis in skin rejuvenation. Biochim Biophys Acta Mol Cell Res. 2025;1872(4):119931. doi:10.1016/j.bbamcr.2025.119931

Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol. 2020;13:31-48. doi:10.2147/CCID.S229054

Chu PN, Zhu S, Dai X, Zhu S. A rat model investigation of enhanced facial rejuvenation via PCL microsphere-induced superior collagen neogenesis in the supraperiosteal plane. Aesthet Plast Surg. 2026;50(7):2754-2764. doi:10.1007/s00266-025-05503-6

Converset-Viethel S. A prospective, randomized, controlled, comparative, single-centre study on the safety and effectiveness of Ellansé dermal filler for correction of age-related volume deficit in the mid-face. Single-centre internal study, data on file. 2020.

Kanniyappan H, Rathnayake RAC, Osamor J, Islam M, Wang RR. The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches. Front Bioeng Biotechnol. 2025;13:1679625. doi: 10.3389/fbioe.2025.1679625

Laeschke K. Biocompatibility of microparticles into soft tissue fillers. Semin Cutan Med Surg. 2004;23(4):214-217. PMID: 15745227. doi:10.1016/j.sder.2004.09.005

McCabe MC, Hill RC, Calderone K, et al. Alterations in extracellular matrix composition during aging and photoaging of the skin. Matrix Biol Plus. 2020;8:100041; doi:10.1016/j.mbplus.2020.100041

Moers-Carpi MM, Sherwood S. Polycaprolactone for the correction of nasolabial folds: a 24-month, prospective, randomized, controlled clinical trial. Dermatol Surg. 2013;39(3 Pt 1):457-463. doi:10.1111/dsu.12054

Nicolau PJ, Marijnissen-Hofsté J. Neocollagenesis after injection of a polycaprolactone based dermal filler in a rabbit. Eur J Aesth Med Dermatol. 2013;3(1):19-26. doi: 10.3109/14764172.2014.968586

Sezer S, Sarac G, Gul M, Zayman E, Kapicioglu Y. Comparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat model. J Cosmet Dermatol. 2022;21(8):3327-3333. doi:10.1111/jocd.14664

Sinclair. Data on file. 2025.

Sinclair. Ellansé Instructions for Use (IFU).

Wu X, Wang Q, Lin X, Wang X, Wang D. Safety and efficacy of subcutaneous and intradermal polycaprolactone / carboxymethyl cellulose gel injections. Mater Des. 2026;266:116086. doi:10.1016/j.matdes.2026.116086

Yanatma I, Sarac G, Gul M, Gul S, Kapicioglu Y. Comparison of polycaprolactone and calcium hydroxylapatite dermal fillers in a rat model. Dermatol Ther. 2021;34(1):e14716. doi:10.1111/dth.14716

Zou Y, Cao M, Yang S, et al. Polycaprolactone microspheres promote hyaluronic acid synthesis in fibroblasts via FOXA1 O-GlcNAcylation. Mater Des. 2026;:doi: 10.1016/j.bbamcr.2025.119931