Questions People Ask
There are real benefits to Ellansé, though only your doctor can say
if it's the right choice for you.
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Ellansé is made of round and smooth polycaprolactone (PCL) microspheres held in a soft carboxymethyl cellulose (CMC) gel. The gel gives a smooth result you can see straight away, while the microspheres gently encourage your skin to build its own collagen over the following months. Both are gradually broken down and cleared by your body — nothing permanent is left behind.¹˒²
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Most collagen-stimulating treatments are judged on one thing: how much collagen they make. Ellansé starts from a different question — what kind of collagen, and where. It is designed to help your skin rebuild the strong, structured collagen that healthy skin relies on, in the areas where support has been lost. The aim is a result that looks like your own skin, not like something added on top.²˒³
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Ellansé has been used by physicians for more than 17 years across a large number of countries, so there is a large body of real-world experience behind it. As with any injectable procedure, side effects are possible. The most important step is a consultation: a trained physician will review your health and whether Ellansé suits you. The full list of contraindications, warnings and precautions is in the Instructions for Use.¹
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No. According to the Instructions for Use, Ellansé should not be injected in the lips, the area around the eyes, the glabella or the neck. These areas carry a higher risk, and your physician will guide you on where treatment is appropriate for you.
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Ellansé works in two complementary ways. First, it helps your skin build its own strong, structured collagen in the areas where support has faded.³˒⁴ Alongside that, laboratory research suggests it may also support your skin's natural hydration environment.⁵ Together these contribute to firmer, healthier-looking skin — built by your own biology, gradually, over months.
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The CMC gel gives you a visible result straight away.¹ The PCL microspheres then act as a gentle scaffold that encourages your own skin to produce new collagen and extracellular matrix components over the following months.⁴˒⁵ As the material is gradually and naturally cleared by your body, the newly formed collagen and ECM structure may persist — so the result is designed to evolve, not simply fade.¹
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Ellansé is used in the face. The specific areas that may be treated are set out in the approved product information for your market, and your physician will decide what is appropriate for you.
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Discomfort varies from person to person. The product is injected with a fine needle or cannula, and your physician can talk you through comfort measures beforehand.
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Your physician will give you aftercare instructions. These usually include limiting exposure of the treated area to strong sun, UV lamps and extreme cold until any initial swelling or redness has settled.
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Ellansé should not be used at, or close to, sites where other skin augmentation procedures have been carried out. Tell your physician about any previous treatments so they can advise you.
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As with any procedure of this type, adverse events are possible, though not everyone experiences them. These can include injection-site reactions such as redness, swelling, bruising, tenderness or lumps. Rare but serious events have been reported. Your physician will talk you through the risks, and the full list appears in the Instructions for Use.
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No. Ellansé is biodegradable — it is gradually absorbed and cleared by your body over time, while the collagen your skin forms may persist.⁵
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Ellansé is not suitable for everyone. Your physician will review your medical history, medications and the area you want treated before advising you. Refer to the Instructions for Use for the full list of contraindications, warnings and precautions.
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Only from a trained healthcare professional. Use the clinic finder to speak to a physician near you. Availability varies by country.
This page does not provide medical advice and does not replace a consultation with a qualified healthcare professional. Indications, availability and approved duration wording vary by market and are subject to the current local Instructions for Use.
NEXT STEP→
Find an Ellansé physician.
Ellansé is administered only by trained healthcare professionals. Your physician will advise whether it is suitable for you.
STILL DECIDING?
Read the common questions.
What the treatment involves, how long it takes, and what to ask at your consultation.
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Ellansé Instructions for Use (IFU). Sinclair.
Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol. 2020;13:31-48. doi:10.2147/CCID.S229054.
Kanniyappan H, Rathnayake RAC, Osamor J, Islam M, Wang RR. The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches. Front Bioeng Biotechnol. 2025;13:1679625. doi:10.3389/fbioe.2025.1679625.
Cao M, Tao L, Zhang Y, et al. Increasing collagen synthesis in fibroblasts: the roles of PCL microspheres and the SAMD11-PLOD1 axis in skin rejuvenation. Biochim Biophys Acta Mol Cell Res. 2025;1872(4):119931. doi:10.1016/j.bbamcr.2025.119931.
Zou Y, Cao M, Yang S, et al. Polycaprolactone microspheres promote hyaluronic acid synthesis in fibroblasts via FOXA1 O-GlcNAcylation. Mater Des. 2026;268:116452.