Built From Within

A CMC (carboxymethyl cellulose) gel that works right away.

PCL (polycaprolactone) microspheres that act as a scaffold for forming your own collagen.¹‧²‧³

THE MATERIAL

Precision-engineered PCL microspheres.

Powered by STAT Patent Technology.

The result starts with the material. Ellansé's PCL microspheres are made with our proprietary STAT Technology™ — a patented process that makes every microsphere evenly shaped and smooth. They're carried into the body in the CMC gel, so what goes in is consistent, and your skin responds gently and predictably.¹‧²

  • A precisely calibrated microsphere size - small, consistent, and even.¹‧²

  • Round, uniform spheres with a smooth surface - for a gentle, even response in the skin.¹‧²

  • Broken down gently from the inside out, then naturally cleared by your body.¹‧¹²

THE PATHWAYS

Two Regeneration Pathways

Ellansé supports your skin’s own collagen and natural hydration for better tissue environment and skin quality, creating a better environment for tissue to rebuild.

COLLAGEN REGENERATION

Helps your skin build its own strong, structured collagen over time

In vitro studies suggest a candidate axis(SAMD11–PLOD1) supports this maturation.²‧³‧⁷

HYALURONIC ACID RENEWAL

Supports the skin’s natural hydration and moisture retention

In vitro studies suggest PCL biodegradation may aid your skin's own HA synthesis.⁸

Ellansé aims to help you build your own collagen

BEYOND COLLEGAN

PCL AND ECM REMODELLING

ECM stands for extracellular matrix — the web of proteins that sits between your skin cells and holds everything together. It's the scaffolding under your skin: when it's strong, skin stays firm; when it weakens with age, skin loses its support. Research with PCL-based microspheres has identified effects across six components involved in extracellular matrix remodelling.²‧¹⁰

PCL Supports 6 ECM Components

  • Structural Support²‧³

  • Soft And Plump²‧⁵

  • The Anchor That Holds Skin Layers Together⁹

  • The Spring That Helps Skin Return To Shape⁶

  • A native water-binding component of the ECM⁸

  • Blood Supply Signals Observed In Tissue Studies⁴‧¹⁰

Based on preclinical / in vitro studies. Clinical relevance remains under investigation.

THE OUTCOME

Ellansé helps your skin build the right collagen, in the right place.²‧³‧⁵

Type I Collagen Dominant:

Strong, structured, healthy collagen

WHAT, WHERE, HOW

Your skin can produce collagen after an injury but scar collagen is disorganized, stiff, and not what makes skin look youthful.

Ellansé is developed under these principles

01

Precision Biology

A clear defined pathway to explain how collagen is regenerated.

MORE ON SAFETY

02

ECM Tissue Architecture

High-quality collagen, and organised, integrated, vascularised tissue that becomes part of the body.

ELLANSÉ PHILOSOPHY

03

Established Safety

Low-inflammatory biology, complete metabolism. backed-up by real-world experience.

NEXT STEP→

Find an Ellansé physician

Ellansé is administered only by trained healthcare professionals. Your physician will advise whether it is suitable for you.

CONTACT US

STILL DECIDING？

Frequently Asked Questions

What the treatment involves, how long it takes, and what to ask at your consultation.

READ THE FAQ

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    2. Kanniyappan H, Rathnayake RAC, Osamor J, Islam M, Wang RR. The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches. Front Bioeng Biotechnol. 2025;13:1679625. doi:10.3389/fbioe.2025.1679625.

    3. Nicolau PJ, Marijnissen-Hofste J. Neocollagenesis after injection of a polycaprolactone based dermal filler in a rabbit. Eur J Aesth Med Dermatol. 2013;3(1):19-26.

    4. Yanatma I, Sarac G, Gul M, Gul S, Kapicioglu Y. Comparison of polycaprolactone and calcium hydroxylapatite dermal fillers in a rat model. Dermatol Ther. 2021;34(1):e14716. doi:10.1111/dth.14716.

    5. Sezer S, Sarac G, Gul M, Zayman E, Kapicioglu Y. Comparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat model. J Cosmet Dermatol. 2022;21(8):3327-3333. doi:10.1111/jocd.14664.

    6. Chu PN, Zhu S, Dai X, Zhu S. A rat model investigation of enhanced facial rejuvenation via PCL microsphere-induced superior collagen neogenesis in the supraperiosteal plane. Aesthet Plast Surg. 2026;50(7):2754-2764. doi:10.1007/s00266-025-05503-6.

    7. Cao M, Tao L, Zhang Y, et al. Increasing collagen synthesis in fibroblasts: The roles of PCL microspheres and the SAMD11-PLOD1 axis in skin rejuvenation. Biochim Biophys Acta Mol Cell Res. 2025;1872(4):119931. doi:10.1016/j.bbamcr.2025.119931.

    8. Zou Y, Cao M, Yang S, Wu M, Zhou H, Wu S, You W, Zhang Y, Ju Z, Ge Y, Gao X, Luo S. Polycaprolactone microspheres promote hyaluronic acid synthesis in fibroblasts via FOXA1 O-GlcNAcylation. Mater Des. 2026;268:116452.

    9. Wu X, Wang Q, Lin X, Wang X, Wang D. Safety and efficacy of subcutaneous and intradermal polycaprolactone / carboxymethyl cellulose gel injections. Mater Des. 2026;266:116086. doi:10.1016/j.matdes.2026.116086.

    10. Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol. 2020;13:31-48. doi:10.2147/CCID.S229054.

    11. Converset-Viethel S. A prospective, randomized, controlled, comparative, single-centre study on the safety and effectiveness of Ellansé dermal filler for correction of age-related volume deficit in the mid-face. Single-centre internal study, data on file. 2020.

    12. Ellansé Instructions for Use (IFU). Sinclair.