The Next Generation of Biostimulation

Ellansé not simply supports collagen production,

but creates the right biological conditions for

tissue to rebuild itself.

Ellansé is about creating the condition

in which the tissue can rebuild itself

1.2.3

What Happens After Treatment?

Immediate Correction

The CMC (carboxymethyl cellulose) gel carrier provides visible correction immediately after treatment. ¹‧⁶

02

01

03

Collagen Response Over Time

The PCL (polycaprolactone) microspheres help support collagen formation gradually. ¹‧²

Results Evolution

As collagen develops, the result may become more integrated and natural-looking over time. Results that can last around 24 months with Ellansé M. ⁵‧⁷

Immediate results you can see and a gradual, collagen-supported result over time.

Established Safety⁸

17+

YEARS IN CLINICAL USE

5.1M+

SYRINGES DISTRIBUTED

Sinclair data on file, 2025. Availability varies by market.

70+

COUNTRIES

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Find an Ellansé physician

Ellansé is administered only by trained healthcare professionals. Your physician will advise whether it is suitable for you.

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Frequently Asked Questions

What the treatment involves, how long it takes, and what to ask at your consultation.

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    1. Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol. 2020;13:31-48. doi:10.2147/CCID.S229054.

    2. Cao M, Tao L, Zhang Y, et al. Increasing collagen synthesis in fibroblasts: the roles of PCL microspheres and the SAMD11-PLOD1 axis in skin rejuvenation. Biochim Biophys Acta Mol Cell Res. 2025;1872(4):119931. doi:10.1016/j.bbamcr.2025.119931.

    3. Chu PN, Dai S, Dai X, Zhu S. A rat model investigation of enhanced facial rejuvenation via PCL microsphere-induced superior collagen neogenesis in the supraperiosteal plane. Aesthet Plast Surg. 2026;50(7):2754-2764. doi:10.1007/s00266-025-05903-6.

    4. McCabe MC, Hill RC, Calderone K, et al. Alterations in extracellular matrix composition during aging and photoaging of the skin. Matrix Biol Plus. 2020;8:100041. doi:10.1016/j.mbplus.2020.100041.

    5. Ellansé Instructions for Use (IFU). Sinclair.

    6. Laeschke K. Biocompatibility of microparticles into soft tissue fillers. Semin Cutan Med Surg. 2004;23(4):214-217. doi:10.1016/j.sder.2004.09.005. PMID: 15745227.

    7. Moers-Carpi MM, Sherwood S. Polycaprolactone for the correction of nasolabial folds: a 24-month, prospective, randomized, controlled clinical trial. Dermatol Surg. 2013;39(3 Pt 1):457-463. doi:10.1111/dsu.12054.

    8. Sinclair Vigilance Data on File: 2025. AE, adverse event.